C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/10 (2006.01) C07K 14/47 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12N 15/66 (2006.01) C12N 15/67 (2006.01) C12Q 1/68 (2006.01) G06F 17/00 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2407745
Methods and compositions for the identification, isolation and characterization of regulatory DNA sequences in a cell of interest are provided. Also provided are libraries of regulatory sequences obtained according to the methods, and databases comprising collections of regulatory sequences for a particular cell of interest. In addition, various uses for the regulatory sequences so obtained, and uses for the databases of regulatory sequences, are provided. Also disclosed are computer systems and computer program products for utilizing the databases to conduct various genetic analyses, and uses of accessible regulatory sequences in the design of vectors bearing transgenes.
Procédés et compositions servant à effectuer l'identification, l'isolation et la caractérisation de séquences d'ADN régulatrices dans une cellule définie. L'invention concerne également des banques de séquences régulatrices obtenues au moyen de ces procédés, ainsi que des bases de données contenant des regroupements de séquences régulatrices pour une cellule déterminée. De plus, elle concerne différentes utilisations des séquences régulatrices obtenues et des mises en application des bases de données de ces séquences régulatrices. Elle concerne également des systèmes informatiques et des programmes informatiques servant à utiliser ces bases de données afin d'exécuter différentes analyses génétiques, et d'utiliser les séquences régulatrices accessibles pour la conception de vecteurs portant des transgènes.
Urnov Fyodor
Wolffe Alan P.
Gowling Lafleur Henderson Llp
Sangamo Biosciences Inc.
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