Daunomycin and adriamycin sulfono and sulfoxo analogues

Details Daunomycin and adriamycin sulfono and sulfoxo analogues Daunomycin and adriamycin sulfono and sulfoxo analogues

C - Chemistry, Metallurgy

07

H

260/328, 260/230

C07H 15/26 (2006.01) C07D 311/78 (2006.01) C07H 15/252 (2006.01)

Patent

CA 1269370

ABSTRACT This invention provides novel compounds of the formula (I): Image (I) including all stereoisomers thereof, and pharmaceutically ac- ceptable salts thereof, wherein, of A and B , one is C=O and the other is SW-Y; R is hydrogen, hydroxy or methoxy; R1 is hydrogen or hydroxy; R2 is hydrogen or hydroxy; X is hydrogen, hydroxy or methoxy and Y is O or °2; provided that R and X do not both stand for methoxy. These compounds show potent growth inhibition activity against P-388 leukemia cells and are therefore potentially useful in the treatment of cancer.

523113

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