Daunorubicine derivatives, preparation process and...

C - Chemistry – Metallurgy – 07 – H

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260/208.2

C07H 15/24 (2006.01) C07H 15/252 (2006.01)

Patent

CA 1118414

PRECIS DE LA DIVULGATION: La présente invention concerne de nouveaux dérivés de la daunorubicine de formule générale (I) Image (I) dans laquelle R1 est un radical de formule générale (II) Image (II) dans laquelle les symboles X représentent l'atome d'oxygène ou de soufre, les symboles R3 sont des radicaux alcoyle ou for- ment ensemble un radical alcoylène, et R2 est un radical de formule générale (III) Image (III) dans laquelle R4 est un radical alcoyle, leurs formes diastéréoisomères et leurs mélanges, leurs sels, leur préparation et les compositions pharmaceutiques qui les contiennent. Ces nouveaux dérivés sont particulièrement utiles comme agents antitumoraux.

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