Dbait and its standalone uses thereof

Details Dbait and its standalone uses thereof Dbait and its standalone uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 38/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2673972

The invention relates to compositions and methods for interfering with the DNA repair of double strand breaks (DSBs). The invention discloses double-stranded nucleic acid molecules that act as baits and hijack the holocomplex of enzymes responsible of DNA DSB sensing, signaling and/or repair pathways, in particular the non homologous end joining (NHEJ) pathway of DSB repair. The invention discloses the use of these molecules as a standalone anticancer drug in an efficient amount to be introduced in the tumor cell nuclei in order to trigger their death.

L'invention concerne des compositions et des méthodes destinées à interférer avec la réparation de cassures double brin (CDB) d'ADN. L'invention concerne de nouvelles molécules d'acides nucléiques double brin agissant comme appâts et détournant l'holocomplexe d'enzymes responsables des voies de détection, de signalisation et/ou de réparation des CDB de l'ADN, et notamment la voie de réparation des CDB par recombinaison non homologue (NHEJ). L'invention concerne l'utilisation de ces molécules comme médicament anticancéreux indépendant en dose efficace à introduire dans les noyaux des cellules tumorales en vue d'en déclencher la mort.

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