Dc 107 derivatives (1)

Details Dc 107 derivatives (1) Dc 107 derivatives (1)

C - Chemistry, Metallurgy

07

D

C07D 513/18 (2006.01) A61K 31/425 (2006.01) A61K 31/675 (2006.01) A61K 31/695 (2006.01) A61K 31/70 (2006.01) C07D 513/20 (2006.01) C07D 519/00 (2006.01) C07F 7/10 (2006.01) C07F 9/6561 (2006.01) C07H 15/26 (2006.01) C07H 17/00 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2245942

DC 107 derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, each having antibacterial and antitumor activities, wherein R1 represents hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR4, etc.; R2 represents hydrogen or COR6; R3 represents -CH2COOR7, phthalimidomethyl, etc.; and W represents oxygen or NR8 (wherein R8 represents hydroxy, lower alkoxy, lower alkenyloxy, aralkyloxy, optionally substituted arylsulfonylamino or lower alkoxycarbonylamino).

La présente invention concerne des dérivés DC 107, représentés par la formule générale (I), ou certains de leurs sels pharmaceutiquement admis, ces dérivés et leurs sels présentant des activités antibactériennes et antitumorales. Dans cette formule générale R?1¿ est notamment hydrogène, alcoxyalkyl inférieur, aralcoxyalkyl, alcoxyalcoxyalkyl inférieur, alcoxyalcoxyalcoxyalkyl inférieur, aralkyl, tétrahydropyranyl, COR?4¿; R?2¿ est hydrogène ou COR?6¿; R?3¿ est notamment -CH¿2?COOR?7¿, phthalimidométhyl; et W est oxygène ou NR?8¿. Pour NR?8¿, R?8¿ est hydroxy, alcoxy inférieur, alcényloxy, aralkyloxy, arylsulfonylamino ou alcoxycarbonulamino éventuellement substitués.

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