Dc-stamp antibodies

Details Dc-stamp antibodies Dc-stamp antibodies

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 19/08 (2006.01)

Patent

CA 2760330

Provided herein are antibodies that specifically bind an epitope of DC-STAMP. Specifically, provided herein are monoclonal antibodies that bind an epitope of DC-STAMP, wherein the epitope comprises the amino acid sequence Glu-Val-His-Leu-Lys-Leu-His-Gly-Glu-Lys-Gln-Gly-Thr-Gln (SEQ ID NO:1). Optionally, the epitope comprises the amino acid sequence His-Gly-Glu-Lys-Gln-Gly-Thr-Gln (SEQ ID NO:2). Optionally, the epitope comprises the amino acid sequence Lys-Gln-Gly-Thr-Gln (SEQ ID NO:3).

La présente invention porte sur des anticorps qui se lient spécifiquement à un épitope de DC-STAMP. De façon spécifique, la présente invention porte sur des anticorps monoclonaux qui se lient à un épitope de DC-STAMP, l'épitope comprenant la séquence d'acides aminés Glu-Val-His-Leu-Lys-Leu-His-Gly-Glu-Lys-Gln-Gly-Thr-Gln (SEQ ID NO:1). Facultativement, l'épitope comprend la séquence d'acides aminés His-Gly-Glu-Lys-Gln-Gly-Thr-Gln (SEQ ID NO:2). Facultativement, l'épitope comprend la séquence d'acides aminés Lys-Gln-Gly-Thr-Gln (SEQ ID NO:3).

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