Dcr5, a bmp-binding protein, and applications thereof

Details Dcr5, a bmp-binding protein, and applications thereof Dcr5, a bmp-binding protein, and applications thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2339968

DCR5, a protein related to DAN (Differential-screening-selected gene Aberrative in Neuroblastoma) and related nucleic acids are provided. Included are natural DCR5 homologs from several species and proteins comprising a DCR5 domain having specific activity, particularly the ability to antagonize a bone morphogenetic protein. The proteins may be produced recombinantly from transformed host cells with the subject nucleic acids. Also provided are isolated hybridization probes and primers capable of specifically hybridizing with the disclosed genes, specific binding agents and methods of making and using the subject compositions.

L'invention concerne DCR5, une protéine associée à DAN (gène choisi de criblage différentiel et d'aberration dans le neuroblastome), ainsi que des acides nucléiques associés. L'invention concerne également des homologues naturels de DCR5, provenant de plusieurs espèces, ainsi que des protéines comprenant un domaine DCR5 possédant une activité spécifique, notamment la capacité d'antagoniser une protéine morphogénétique de l'os. On peut produire ces protéines de manière recombinée, à partir de cellules hôtes transformées au moyen desdits acides nucléiques. L'invention concerne encore des sondes et amorces isolées d'hybridation, capables de s'hybrider spécifiquement avec les gènes décrits, des agents de liaison spécifiques, ainsi que des procédés de préparation et d'utilisation desdites compositions.

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