De novo synthesis of conjugates

Details De novo synthesis of conjugates De novo synthesis of conjugates

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2679473

The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.

L'invention concerne des procédés pour la préparation de médicaments à petites molécules chimiquement modifiés par une fixation covalente d'un oligomère hydrosoluble obtenu à partir d'une composition d'oligomère hydrosoluble. De tels médicaments sont produits par la modification d'une voie synthétique pour fixer l'oligomère à un composé intermédiaire, suivi de la complétion de la voie synthétique.

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