Deacetylcolchicine derivatives

Details Deacetylcolchicine derivatives Deacetylcolchicine derivatives

C - Chemistry, Metallurgy

07

C

C07C 235/08 (2006.01) A61K 31/16 (2006.01) A61K 31/70 (2006.01) C07C 235/14 (2006.01) C07D 317/32 (2006.01) C07H 7/033 (2006.01) C07H 13/04 (2006.01)

Patent

CA 2058060

Abstract of the Disclosure Deacetylcolchicine derivatives represented by the formula Image (I) wherein R denotes a residue obtained by removing COOH from a C3-C7 sugar carboxylic acid, and a hydroxyl group present in the residue may properly be protected with a protecting group of the hydroxyl group. Said deacetylcolchicine derivatives have less toxicity and strong effect for inhibiting proliferation of tumor cells, and are expected to be used as an antitumor agent.

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