Deacylation of lps in gram negative bacteria

Details Deacylation of lps in gram negative bacteria Deacylation of lps in gram negative bacteria

C - Chemistry, Metallurgy

12

N

C12N 9/16 (2006.01) A61K 35/74 (2006.01) A61K 39/10 (2006.01) C12N 15/63 (2006.01) C12P 1/04 (2006.01)

Patent

CA 2590906

The current invention provides new Gram negative polypeptides exhibiting lipid A 3-O-deacylase activity and are capable of modifying and/or detoxifying gram negative LPS. The present invention also provides Gram negative bacteria, Gram negative bacterial lipopolysaccharides (LPS) and compositions comprising LPS, which are provided with or treated with a 3-O-deacylase activity according to the invention and which may be used for pharmaceutical and/or veterinary purposes, in particular for the preparation of whole cell or acellular vaccines against pathogenic Gram negatives such as Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.

L'invention concerne de nouveaux polypeptides Gram-négatifs présentant une activité 3-O-déacylase de lipide A et capables de modifier et/ou de détoxifier des lipopolysaccharides bactériens Gram-négatifs (LPS). L'invention concerne également des bactéries Gram-négatives, des LPS Gram-négatifs et des compositions comprenant lesdits LPS qui présentent une activité 3-O-déacylase ou sont traités par celle-ci, et qui peuvent être utilisés à des fins pharmaceutiques et/ou vétérinaires, en particulier, pour des vaccins à cellules entières ou acellulaires contre des pathogènes Gram-négatifs, tels que Bordetella pertussis, Bordetella parapertussis et Bordetella bronchiseptica.

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