Death domain containing receptor 5

Details Death domain containing receptor 5 Death domain containing receptor 5

A - Human Necessities

61

K

A61K 39/00 (2006.01) A01N 37/18 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) C07K 14/52 (2006.01) C07K 14/525 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2369371

The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR5 acitivity.

Cette invention se rapporte à de nouvelles protéines du récepteur 5 contenant le domaine de l'apoptose (DR5), qui font partie de la famille des récepteurs du facteur de nécrose tumoral (TNF) et dont on a démontré qu'elles se lient à la molécule TRAIL. Cette invention concerne en particulier des molécules d'acide nucléique codant ces protéines DR5 humaines, des polypeptides de DR5, ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison pour produire ces polypeptides. Cette invention se rapporte également à des procédés de criblage permettant d'identifier des agonistes et des antagonistes de l'activité de DR5.

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