Death domain containing receptors

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/00 (2006.01) A61K 39/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2371114

The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.

La présente invention concerne de nouvelles protéines de récepteurs contenant un domaine de mort cellulaire (DR3 et DR3-V1), qui sont des membres de la famille des récepteurs du facteur nécrosant des tumeurs (TNF). En particulier, l'invention concerne des molécules d'acides nucléiques isolées qui codent pour les protéines humaines DR3 et DR3-V1. Des polypeptides de DR3 et de DR3-V1 sont également décrits ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison permettant de produire ceux-ci. L'invention concerne en outre des procédés de criblage pour identifier des agonistes et des antagonistes de l'activité de DR3 et de DR3-V1.

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