Death domain containing receptors

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/28 (2006.01) A61K 38/19 (2006.01) C07H 21/04 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2249182

The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.

La présente invention se rapporte à de nouvelles protéines réceptrices (DR3 et DR3-V1) contenant des domaines de mort cellulaire qui sont membres de la famille des récepteurs du facteur de nécrose tumorale (TNF). L'invention se rapporte particulièrement à des molécules d'acides nucléiques isolées codant les protéines humaines DR3 et DR3-V1. L'invention se rapporte également à des polypeptides de DR3 et de DR3-V1 ainsi qu'à des vecteurs, à des cellules hôtes et à des procédés de recombinaison permettant de fabriquer ces protéines. L'invention se rapporte enfin à des procédés de criblage permettant d'identifier des agonistes et des antagonistes de l'activité des protéines DR3 et DR3-V1.

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