Deblocking the common pathway of aromatic amino acid synthesis

Details Deblocking the common pathway of aromatic amino acid synthesis Deblocking the common pathway of aromatic amino acid synthesis

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) C12N 1/21 (2006.01) C12N 9/10 (2006.01) C12N 9/12 (2006.01) C12N 9/88 (2006.01) C12N 15/52 (2006.01) C12N 15/54 (2006.01) C12N 15/60 (2006.01) C12N 15/74 (2006.01) C12P 13/22 (2006.01)

Patent

CA 2148482

Enhanced efficiency of production of aromatic compounds via the common pathway, as shown in the figure, of a host cell is realized by increasing the expression of enzyme special acting on substrate intermediates in identified rate-limiting reaction steps in the pathway. Host cells are transformed with recombinant DNA encoding for the rate-limiting enzymes to provide cell transformants characterized by capacity to produce high concentrations of aromatic metabolites when grown in call culture with a metabolizable carbon source.

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