C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2508632
The inventors have identified intergenically spliced DEC-205/DCL-1 mRNAs, which encode the intact DEC-205 ectodomain together with an additional carbohdrate recognition domain, a transmembrane domain and a cytoplasmic domain derived from DCL-1. These DEC-205/DCL-1 intergenic splice variants were identified on Reed-Sternberg cells and thus have application in the therapy and investigation of Hodgkin~s disease.
L'invention concerne l'identification d'ARNm DEC-205/DCL-1 épissés de manière intergénique. Les ARNm permettent de coder l'ectodomaine intacte DEC-205 avec un domaine de reconnaissance du carbohydrate supplémentaire, un domaine transmembranaire et un domaine cytoplasmique dérivé de DCL-1. Ces variants à épissure intergénique DEC-205/DCL-1 ont été identifiés sur des cellules de Reed-Sternberg et trouvent leur application en thérapie et dans la recherche de la maladie d'Hodgkin.
Hart Derek Nigel John
Kato Masato
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Corporation Of The Trustees Of The Order Of The Sisters Of M
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