Deca- undeca- dodeca and tridecapeptides with thymic activity

Details Deca- undeca- dodeca and tridecapeptides with thymic activity Deca- undeca- dodeca and tridecapeptides with thymic activity

C - Chemistry, Metallurgy

07

K

530/7.06, 530/7.

C07K 14/655 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1187869

ABSTRACT OF THE DISCLOSURE Novel peptides of the formula: Image (I) wherein: A, A' and A" are each independently Gly, D-Ala, D-Leu, or D-Trp, wherein A may optionally be N-alkylated or N-acylated; B is Pro, .DELTA.3-Pro, Thz, or diMeThz; C and C'are each independently Thr, Ser, Val, or alloThr; D is Glu, Gln, Asp, or Asn; R is hydrogen, or is lower alkyl or lower acyl, substituted for one of the hydrogens on the .epsilon.-amino group of the lysyl residue; X is Cys, Ala, ABU, or Cys(Me); and Y is selected from the group consisting of hydroxy, Pro, Pro-Leu, and Pro-Leu-Met, -NH2, ProNH2, Pro-LeuNH2 and Pro-leu-MetNH2; and the pharmaceutically acceptable salts thereof, are useful for increasing immunologic competence. Methods for preparation of the peptides are also described.

392786

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