Decaprenylamine derivatives

Details Decaprenylamine derivatives Decaprenylamine derivatives

C - Chemistry, Metallurgy

07

D

260/308, 260/293

C07D 233/58 (2006.01) C07D 295/02 (2006.01)

Patent

CA 1157859

ABSTRACT New pharmaceutically active decaprenylamines having the general formula: Image (I) wherein R is a group capable of forming, together with the adjacent nitrogen atom, a 5- or 6-membered heterocyclic ring which may optionally contain a further hetero atom selected from the group consisting of nitrogen, oxygen and sulfur, the radical R being optionally substituted with a hydrogen atom or a lower alkyl or decaprenyl group when it contains an additional nitrogen atom as the further hetero atom, and the pharmaceutically acceptable acid addition salts thereof, are prepared by converting decaprenol of the formula: Image (II) into a corresponding halide or sulfonic acid ester which is thereafter reacted with a heterocyclic compound containing at least one primary or secondary amino group and having the general formula: Image (III) wherein R has the aforesaid meaning, in the presence or absence of a base, when a pharmaceutically acceptable acid addition salt is desired, the decaprenylamine of the formula (I) thus obtained is further reacted with a pharmaceutically acceptable acid to provide the desired salt. The decaprenyl- amines of the formula (i) are useful for controlling virus infection of vertebrate animals.

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