A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/36 (2006.01) C12N 5/071 (2010.01) A61K 35/36 (2006.01)
Patent
CA 2677229
In certain embodiments, the present invention relates to a process for preparing skin removed from a human donor and removing cellular components and forming a decellular matrix having as major components collagens and elastins while disinfecting the tissue. In a particular embodiment, the process comprises the following: (1) removing hair from the skin; (2) decellularizing the skin including inspection for visual defects; (3) soaking the tissue in a detergent and rinsing same with sterile water; (4) disinfecting the skin in a disinfection solution containing about 0.5% to about 0.7% peracetic acid; and (5) processing the tissue by cutting the tissue to size.
Dans certains modes de mise en oeuvre, la présente invention concerne un processus visant à préparer la peau prélevée chez un donneur humain et à retirer des composants cellulaires et former une matrice de décellularisation possédant comme composants principaux des collagènes et des élastinee tout en désinfectant le tissu. Selon un mode de mise en oeuvre particulier, le processus consiste à : (1) épiler la peau; (2) décellulariser la peau en inspectant les défauts visuels; (3) faire tremper le tissu dans un détergent et le rincer avec de l'eau stérile; (4) désinfecter la peau dans une solution de désinfection contenant d'environ 0,5 % à environ 0,7 % d'acide peracétique et (5) traiter le tissu en le découpant à une dimension.
Gertzman Arthur
Kawas Michael
Sunwoo Moon Hae
Truncale Katherine G.
Gertzman Arthur
Kawas Michael
Moffat & Co.
Musculoskeletal Transplant Foundation
Ngo,manh-Dan
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