A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/38 (2006.01) A61L 27/36 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2491528
An objective of the present invention is to overcome a problem that there is an inverse relationship between the decellularization rate and the strength of tissue. This problem was solved by immersing tissue in a solution containing a non-micellar amphipathic molecule (e.g., a 1,2-epoxide polymer). Thus, the present invention provides decellularized tissue, in which the cell survival rate of the tissue is less than a level at which calcification or an immune reaction is elicited in an organism and the tissue damage rate of the tissue is suppressed to a level which permits clinical applications. Tissue prepared by the above-described treatment preferably retains a certain level of tissue strength. Further, the tissue of the present invention has an effect of performing cell replacement.
Selon l'invention, le problème de la relation inverse entre le taux de décellularisation et la résistance d'un tissu se résout par immersion du tissu dans une solution contenant une molécule amphipathique non-micellaire (par exemple, un polymère 1,2-epoxyde). Ainsi, l'invention concerne un tissu décellularisé, dans lequel le taux de survie cellulaire du tissu est inférieur à un niveau où la calcification ou une réaction immunitaire provoquée dans un organisme et le taux de dégradation tissulaire du tissu est supprimé à un niveau qui permet des applications cliniques. Le tissu ainsi préparé conserve de préférence un certain niveau de résistance tissulaire. En outre, le tissu selon l'invention facilite le remplacement cellulaire.
Hara Masayuki
Iwai Shigemitsu
Matsuda Hikaru
Miyake Jun
Sawa Yoshiki
Cardio Inc.
National Institute Of Advanced Industrial Science And Technology
Sim & Mcburney
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