Decellularized vascular prostheses

Details Decellularized vascular prostheses Decellularized vascular prostheses

A - Human Necessities

61

L

A61L 27/36 (2006.01) A61L 27/38 (2006.01) A61L 27/50 (2006.01)

Patent

CA 2407328

The present invention relates to decellularized vascular prostheses that are resistant to thrombus occlusion and have a low level of immunogenicity. The vascular prostheses are denuded of cells, and coated with an anti-thrombogenic agent and a growth factor that promotes recellularization and further reduces the immunogenicity. The prostheses have high mechanical strength, resist aneurysm rupture, and allow for secure surgical sutures while maintaining structural integrity. The present invention provides vascular prostheses that are blood vessels, valves or portions of vessels containing valves. The present invention is also useful for coating synthetic vascular stents.

La présente invention concerne des prothèses vasculaires décellularisées résistantes à une occlusion due à un thrombus et possédant un faible niveau d'antigénicité. Les prothèses vasculaires sont privées de leur membrane cellulaire et revêtues d'un agent anti-thrombogénique et d'un facteur de croissance qui favorise le recellularisation et diminue encore plus l'antigénicité. Ces prothèses possèdent une résistance médicale élevée, résistent aux ruptures d'anévrisme et permettent des sutures chirurgicales solides tout en respectant l'intégrité structurelle. Les prothèses vasculaires de l'invention sont des vaisseaux sanguins, des valvules ou des parties de vaisseaux contenant des valvules. L'invention s'avère également utile pour l'enrobage d'extenseurs vasculaires synthétiques.

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