Decorin binding protein compositions and methods of use

Details Decorin binding protein compositions and methods of use Decorin binding protein compositions and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A01K 67/027 (2006.01) A61K 31/70 (2006.01) A61K 39/02 (2006.01) A61K 39/40 (2006.01) A61K 48/00 (2006.01) C07K 14/20 (2006.01) C07K 16/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2218492

Disclosed are the dbp gene and dbp-derived nucleic acid segments from Borrelia burgdorferi, the etiological agent of Lyme disease, and DNA segments encoding dbp from related borrelias. Also disclosed are decorin binding protein compositions and methods of use. The DBP protein and antigenic epitopes derived therefrom are contemplated for use in the treatment of pathological Borrelia infections, and in particular, for use in the prevention of bacterial adhesion to decorin. DNA segments encoding these proteins and anti-(decorin binding protein) antibodies will also be of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of Borrelia colonization in an animal. These DNA segments and the peptides derived therefrom are contemplated for use in the preparation of vaccines and, also, for use as carrier proteins in vaccine formulations, and in the formulation of compositions for use in the prevention of Lyme disease.

La présente invention concerne le gène dbp et des segments, dérivés du dbp, d'acide nucléique provenant de Borrelia burgdorferi, l'agent étiologique de la maladie de Lyme, et des segments d'ADN codant le dbp provenant de borrelias voisins. L'invention concerne aussi des compositions de protéines fixant la décorine et des procédés d'utilisation. Il est envisagé d'utiliser la protéine DBP et des épitopes antigéniques qui en sont dérivés dans le traitement des infections pathologiques par Borrelia et, en particulier, dans la prévention de l'adhésion bactérienne à la décorine. Les segments d'ADN qui codent ces protéines et des anticorps anti-(protéines fixant la décorine) seront également utiles dans diverses applications de criblage, de diagnostic et de thérapeutique, notamment l'immunisation active et passive et les procédés de prévention de la colonisation par Borrelia chez un animal. Il est envisagé d'utiliser ces segments d'ADN et les peptides qui en sont dérivés dans la préparation de vaccins et, aussi, comme protéines vectrices dans les formulations de vaccins, ainsi que dans la formulation de compositions destinées à la prévention de la maladie de Lyme.

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