Decorin fragments and methods of inhibiting cell regulatory...

Details Decorin fragments and methods of inhibiting cell regulatory... Decorin fragments and methods of inhibiting cell regulatory...

C - Chemistry, Metallurgy

07

K

C07K 14/71 (2006.01) A61K 38/17 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2132859

2132859 9320202 PCTABS00027 The present invention provides a method of inhibiting an activity of a cell regulatory factor comprising contacting the cell regulatory factor with a purified polypeptide, wherein the polypeptide comprises a cell regulatory factor binding domain of a protein. The protein is characterized by a leucine-rich repeat of about 24 amino acids. In a specific embodiment, the present invention relates to the ability of decorin, a 40,000 dalton protein that usually carries a glycosaminoglycan chain, and more specifically to active fragments of decorin or its functional equivalents to bind TGF.beta.. The invention also provides a cell regulatory factor designated MRF. Also provided are methods of identifying, detecting and purifying cell regulatory factors and proteins which bind and effect the activity of cell regulatory factors.

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