Decoy nucleic acid to synoviolin gene promoter

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 21/00 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2561117

A decoy nucleic acid to a synoviolin gene promoter; a decoy nucleic acid capable of binding to the transcriptional factor of the synoviolin gene promoter and thus inhibiting the promoter activity; and (a) a decoy nucleic acid comprising a base sequence represented by SEQ ID NO:11 or 12, or (b) a decoy nucleic acid comprising a base sequence derived from a base sequence represented by SEQ ID NO:11 or 12 by deletion, substitution or addition of one to several base and having a function of inhibiting the promoter activity.

Il est prévu un acide nucléique leurre pour promoteur de gène synoviolin ; un acide nucléique leurre capable de se lier au facteur de transcription du promoteur de gène synoviolin et ainsi d~inhiber l~activité de promotion ; et (a) un acide nucléique leurre comprenant une séquence de base représentée par ID SEQ NO:11 ou 12, ou (b) un acide nucléique leurre comprenant une séquence de base déduite d~une séquence de base représentée par ID SEQ NO : 11 ou 12 par effacement, substitution ou addition d~une ou de plusieurs bases et remplissant une fonction d~inhibition de l~activité de promotion.

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