A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 38/00 (2006.01) A61K 45/00 (2006.01) A61P 11/06 (2006.01) A61P 37/02 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/11 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2483106
A GATA3 decoy whereby the production of Th2 cytokine can be specifically inhibited, a GATA3 mutant protein and medicinal compositions containing the same can be provided by inhibiting the binding of GATA3 to the low affinity GATA3-binding sequence occurring in a Th2 cytokine gene cluster and thus inhibiting the chromatin modeling which is necessary for the stable and sufficient expression of Th2 cytokine.
L'invention concerne un leurre GATA3 permettant d'inhiber de manière spécifique la production de la cytokine Th2, une protéine mutante GATA3 et des compositions médicinales contenant celle-ci, pouvant être obtenus selon une technique consistant à inhiber la liaison de GATA3 à la séquence de liaison à GATA3 de faible affinité apparaissant dans une famille de gènes de la cytokine Th2 et permettant, ainsi, d'inhiber la modélisation de la chromatine nécessaire pour une expression stable et suffisante de la cytokine Th2.
Arai Ken-Ichi
Miyatake Shoichiro
Takemoto Naofumi
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Ginkgo Biomedical Research Institute Co. Ltd.
LandOfFree
Decoys for treating and/or preventing th2 cytokine-related... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Decoys for treating and/or preventing th2 cytokine-related..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Decoys for treating and/or preventing th2 cytokine-related... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1718995