Decreasing cell proliferation by decreasing levels of pp5

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2309888

The invention provides a method of increasing expression of p21WAF1/Cip 1 in cells to decrease proliferation of the cells, the method comprising decreasing levels of PP5 protein in the cells. The invention further provides a method of treating or preventing anabnormal condition resulting from a defect in a tumor suppressor gene in a subject that results in decreased induction of p21WAF1/Cip 1 in the cells of the subject, the method comprising administering to the subject an amount of a compound effective to decrease levels of PP5 protein in the cells of the subject.

L'invention porte sur un procédé de renforcement de l'expression de p21?WAF1/Cip¿ ?1¿ dans des cellules de façon à réduire la prolifération cellulaire, ce procédé consistant à réduire les taux de la protéine PP5 dans les cellules. Cette invention porte également sur un procédé de traitement ou de prévention d'un état anormal du à une anomalie dans un gène suppresseur de tumeur chez un sujet, cet état entraînant une induction réduite de p21 ?WAF1/Cip¿ ?1¿ dans les cellules du sujet. Ce procédé consiste à administrer au sujet une quantité d'un composé efficace permettant de réduire les taux de la protéine PP5 dans les cellules du sujet.

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