Defective adenovirus and corresponding complementation lines

Details Defective adenovirus and corresponding complementation lines Defective adenovirus and corresponding complementation lines

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 39/235 (2006.01) A61K 47/00 (2006.01) A61K 48/00 (2006.01) C07K 14/075 (2006.01) C07K 14/395 (2006.01) C07K 14/47 (2006.01) C07K 14/57 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) C12N 15/861 (2006.01) A61K 35/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2141212

Novel defective adenoviruses for the transfer and expression of an exogenous nucleotide sequence in a host cell or organism. The invention also relates to novel complementation lines and to the process for the preparation of these novel defective adenoviruses and their use in therapy and to a pharmaceutical composition containing same.

La présente invention a pour objet de nouveaux adénovirus défectifs pour le transfert et l'expression d'une séquence nucléotidique exogène dans une cellule ou un organisme hôte. L'invention est également relative à de nouvelles lignées de complémentation et le procédé de préparation de ces nouveaux adénovirus défectifs ainsi que leur usage thérapeutique et une composition pharmaceutique les contenant.

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