Defective adenoviruses including a therapeutic gene and an...

Details Defective adenoviruses including a therapeutic gene and an... Defective adenoviruses including a therapeutic gene and an...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/075 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2201399

Novel adenovirus-derived viral vectors, the preparation thereof, and the use of such vectors in gene therapy, are disclosed. In particular, defective adenoviruses having a genome that includes a first recombinant DNA containing a therapeutic gene and a second recombinant DNA containing an immunoprotective gene, are disclosed.

La présente invention concerne de nouveaux vecteurs viraux dérivés des adénovirus, leur préparation et leur utilisation en thérapie génique. Elle concerne plus particulièrement des adénovirus défectifs dont le génome comprend un premier ADN recombinant contenant un gène thérapeutique et un second ADN recombinant contenant un gène immunoprotecteur.

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