A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/245 (2006.01) C07K 14/035 (2006.01) C12N 7/04 (2006.01) C12N 15/86 (2006.01) C12N 15/869 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2158148
The application provides a pharmaceutical which comprises a mutant non-retroviral virus (particularly HSV-1 and/or HSV-2) whose genome is defective in respect of a gene essential for the production of infectious virus. The virus can infect normal cells and undergo replication and expression of viral antigen genes in those cells but cannot produce normal infectious virus. The pharmaceutical is for prophylactic or therapeutic use in generating an immune response in a subject infected therewith. Where the non-retroviral virus is a herpes simplex virus e.g. HSV-1 or HSV-2, the defect can be in the glycoprotein gH gene. Vaccines and therapeutic pharmaceuticals are provided especially for epithelial, oral, vaginal and nasal administration. Also provided is use of a mutant based on HSV-1 for the preparation of a pharmaceutical for prophylactic ore therapeutic use in generating an immune response in a subject against type-2 HSV infection.
Boursnell Michael Edward Griffith
Inglis Stephen Charles
Minson Anthony Charles
Bereskin & Parr
Cantab Pharmaceuticals Research Limited
LandOfFree
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