Defensins: use as antiviral agents

Details Defensins: use as antiviral agents Defensins: use as antiviral agents

A - Human Necessities

61

K

A61K 35/14 (2006.01) A61K 38/17 (2006.01) C07K 17/00 (2006.01) G01N 33/543 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2487895

The present invention relates to inhibition of viruses, e.g., HIV, using defensins. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, nucleic acids, antisense nucleic acids, and ribozymes, that increase naturally occurring defensin expression or activity, thereby inhibiting HIV in a cell; as well as to the use of expression profiles and compositions in diagnosis and prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.

La présente invention concerne l'inhibition de virus, par ex. du VIH, au moyen de défensines. L'invention a également pour objet des procédés pour identifier et utiliser des agents comprenant des compositions chimiques à petites molécules, des anticorps, des peptides, des acides nucléiques, des acides nucléiques antisens et des ribozymes qui augmentent l'expression ou l'activité de la défensine présente à l'état naturel, ce qui permet d'inhiber le VIH dans une cellule. L'invention concerne aussi l'utilisation de profils d'expression et de compositions dans le cadre du diagnostic, de la prévention et du traitement de l'infection par le VIH et des états pathologiques associés tels que le SIDA.

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