Deffective recombinant adenoviruses with inactivated iva2 gene

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) C07K 14/075 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2197904

The present invention relates to new viral vectors derived from adenoviruses, their preparation and utilization in gene therapy. It relates particularly to deffective recombinant adenoviruses wherein the IVa2 gene at least is inactivated.

La présente invention concerne de nouveaux vecteurs viraux dérivés des adénovirus, leur préparation et leur utilisation en thérapie génique. Elle concerne en particulier des adénovirus recombinants défectifs dans lesquels le gène IVa2 au moins est inactivé.

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