Deglycosylated and desialidated long pentraxin ptx3

Details Deglycosylated and desialidated long pentraxin ptx3 Deglycosylated and desialidated long pentraxin ptx3

C - Chemistry, Metallurgy

07

K

C07K 14/475 (2006.01) A61K 38/17 (2006.01)

Patent

CA 2580426

Deglycosylated long pentraxin PTX3 and desialidated long pentraxin PTX3 are disclosed, as well as processes for their preparation, pharmacological compositions containing them, and their use for the preparation of a medicament for the treatment of diseases in which the use of the long pentraxin PTX is indicated, particularly infectious and inflammatory diseases and female fertility disorders. These proteins are endowed with therapeutic activity superior to that of glycosylated pentraxin.

L'invention concerne une pentraxine longue PTX3 déglycosylée et une pentraxine longue PTX3 désialidée, des procédés d'élaboration correspondants, des compositions pharmacologiques contenant ces substances, et leur utilisation dans la préparation d'un médicament approprié au traitement de maladies pour lesquelles la pentraxine longue PTX est indiquée, en particulier les maladies infectieuses et inflammatoires et les troubles de la fertilité chez la femme. Ces protéines ont une activité thérapeutique supérieure à celle de la pentraxine glycosylée.

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