C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/68 (2006.01) A61K 38/49 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2361334
Disclosed are deglycosylated fragments of a kringle 1-5 region of plasminogen, nucleotides encoding deglycosylated kringle 1-5 region proteins and antibodies specific for deglycosylated kringle 1-5 region proteins. The compositions of the present invention have increased antiangiogenic activity as compared to previously isolated kringle 1-5 region proteins. Also included in the present invention are methods of treating angiogenesis-associated diseases and conditions such as cancer using the compositions described herein.
Cette invention concerne des fragments déglycosylés de la région 1-5 kringle du plasminogène, des nucléotides codant pour des protéines déglycosylées de la région 1-5 kringle et des anticorps spécifiques des protéines déglycosylées de la région 1-5 kringle. Les compositions selon l'invention présentent une activité antiangiogénique supérieure à celles de protéines de la région 1-5 kringle isolées jusqu'ici. L'invention concerne également des méthodes de traitement, au moyen des compositions décrites ici, de maladies et de troubles associés à l'angiogenèse tels que le cancer
Folkman M. Judah
Liang Hong
Macdonald Nicholas J.
Pirie-Shepherd Stephen
Sim Kim Lee
Entremed Inc.
Finlayson & Singlehurst
The Children's Medical Center Corporation
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