Degradable polymeric microsphere composition

A - Human Necessities – 61 – K

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Details

A61K 47/30 (2006.01) A61K 9/50 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2634830

The present invention is directed towards a biodegradable microsphere composition for prolonged controlled release delivery of at least one biologically active agent in vivo. The instant invention provides microspheres prepared from amphiphilic block, star shape or graft copolymers made of poly(N- vinyl-2-pyrrolidone) segment(s) and biodegradable segment(s), the microspheres incorporating at least one biologically active agent and being adapted for controlled delivery of the active agent to a mammal. Poorly water-soluble biologically active agents are incorporated into the microspheres by a single emulsion method. Hydrophilic biologically active agents are incorporated into the microspheres by a double emulsion method. Amphiphilic biologically active agents are incorporated into the microspheres by either a single or double emulsion method.

La présente invention concerne une composition de microbilles à base de polymère biodégradable pour l'administration à libération prolongée contrôlée d'au moins un agent actif in vivo. La présente invention concerne des microbilles préparées à partir de polymères amphiphiles séquencés, en étoile ou greffés réalisés en segment(s) poly(N-vinyl-2-pyrrolidone) ou segment(s) biodégradable(s), les microbilles incorporant au moins un agent biologiquement actif et étant adaptées pour l'administration contrôlée de l'agent actif à un mammifère. Des agents biologiquement actifs peu hydrosolubles sont incorporés dans les microbilles par un procédé d'émulsion simple. Des agents biologiquement actifs hydrophiles sont incorporés dans les microbilles par un procédé d'émulsion double. Des agents biologiquement actifs amphiphiles sont incorporés dans les microbilles soit par un procédé de simple ou double d'émulsion.

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