Degradation of epothilones and ethynyl substituted epothilones

Details Degradation of epothilones and ethynyl substituted epothilones Degradation of epothilones and ethynyl substituted epothilones

C - Chemistry, Metallurgy

12

P

C12P 17/14 (2006.01) C07D 277/24 (2006.01) C07D 277/30 (2006.01) C07D 417/06 (2006.01) C07D 493/04 (2006.01) C07F 7/18 (2006.01) C12P 7/62 (2006.01) C12P 17/18 (2006.01)

Patent

CA 2437707

The invention concerns a process for a degradation of an epothilone C or a epothilone D, wherein an epothilone C or epothilone D is subjected to an olefin metathesis in the presence of ethylene and subsequently an optional ester hydrolysis. The invention further concerns (2-methyl-1,3-thiazol-4-yl)- ethynyl substitued epothilones (9). Formula (9).

La présente invention concerne, dans l'un de ses aspects, un procédé de dégradation d'une épothilone C ou d'une épothilone D. Ledit procédé consiste à soumettre l'épothilone C ou l'épothilone D à une métathèse des oléfines en présence d'éthylène, puis à une éventuelle hydrolyse des esters.

Affiliated with

Also associated with

Rating

Degradation of epothilones and ethynyl substituted epothilones does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Degradation of epothilones and ethynyl substituted epothilones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Degradation of epothilones and ethynyl substituted epothilones will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1597563