Degraded tpo agonist antibody

Details Degraded tpo agonist antibody Degraded tpo agonist antibody

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 7/00 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 15/62 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2424364

A modified antibody containing at least two H chain V domains and at least two L chain V domains of a monoclonal antibody which transduces a signal into cells by crosslinking a TPO receptor to thereby exert TPO agonism. Because of being usable as a TPO signal transduction agonist, this modified antibody is useful as a preventive and/or a remedy for blood diseases in which platelet reduction participates, thrmobopenia following chemotherapy for cancer or leukemia, etc.

L'invention concerne un anticorps modifié contenant au moins deux domaines V de chaîne H et au moins deux domaines V de chaîne L d'un anticorps monoclonal, lequel transduit un signal dans des cellules par réticulation d'un récepteur de la thrombopoïétine (TPO), de manière à agoniser TPO. Etant donné que cet anticorps peut être utilisé en tant qu'agoniste de transduction du signal de TPO, il est utile à titre préventif et/ou curatif dans des maladies du sang dans lesquelles il se produit une réduction des plaquettes, dans la thrombopénie consécutive à une chimiothérapie de cancer ou de leucémie, etc..

Affiliated with

Also associated with

Rating

Degraded tpo agonist antibody does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Degraded tpo agonist antibody, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Degraded tpo agonist antibody will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2057914