Dehydrocholecalciferol derivatives

C - Chemistry – Metallurgy – 07 – B

Patent

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C07B 59/00 (2006.01) A61K 31/045 (2006.01) A61K 31/59 (2006.01) C07C 35/21 (2006.01) C07C 401/00 (2006.01)

Patent

CA 2016985

The novel use of compounds of formula (see formula I) wherein R is H or OH, A is -C~C-, -CH=CH- with E-configuration or -CH2CH2- and R" is H or, where A is -C~C-, R" may also be deuterium, for the treatment of sebaceous gland diseases, such as seborrheic dermatitis and, particularly, acne: a corresponding method of treatment as well as pharmaceutical compositions and commercial packages containing such a compound. Novel compounds of formula I, wherein R" is deuterium.

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