Dehydroepiandrosterone derivatives for preventing...

Details Dehydroepiandrosterone derivatives for preventing... Dehydroepiandrosterone derivatives for preventing...

A - Human Necessities

61

K

A61K 31/56 (2006.01) A61K 31/57 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2223739

The present invention is related to a method for preventing or reducing the effects of ischemia. The ischemia may be associated with injury or reperfusion injury, such as occurs as a result of infarctions, thermal injury (burns), surgical trauma, accidental trauma, hemorrhagic shock and the like. The invention is also related to methods for preventing or reducing bacterial translocation, adult respiratory distress syndrome, adherence of blood cells and platelets to endothelial cells and pulmonary hypertension. In accordance with the present ivnention, these conditions are prevented or reduced by administering dehydroepiandrosterone-3-sulfate (DHEAS) or a DHEA congener.

Procédé de prévention ou de réduction des effets de l'ischémie. Cette ischémie peut être liée à des lésions ou à des lésions dues aux perfusions répétées, telles que celles peuvant survenir à la suite d'infarcissements, de lésions thermiques (brûlures), de traumatismes chirurgicaux ou accidentels, de chocs hémorragiques et d'événements analogues. L'invention concerne également des procédés de prévention ou d'atténuation de la translocation bactérienne, de l'insuffisance respiratoire aiguë des états de choc, de l'adhérence des cellules sanguines et des plaquettes aux cellules endothéliales et de l'hypertension pulmonaire. Selon l'invention, ces états sont prévenus ou atténués par l'administration de déshydroépiandrostérone-3-sulfate (DHEAS) ou d'un congénère de DHEA.

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