Dehydropeptide compounds, their production and their...

Details Dehydropeptide compounds, their production and their... Dehydropeptide compounds, their production and their...

C - Chemistry, Metallurgy

07

K

530/5.06

C07K 5/065 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1147725

ABSTRACT this invention relates to dehydropeptides containing a tryptophan moiety and of the formula I Image (I) or a pharmaceutically acceptable salt thereof, in which R1CO denotes an aliphatic acyl group, R2 denotes an unsubstituted phenyl radical, R3 and R4 both denote a hydrogen atom, or together denote an additional bond between the two carbon atoms, R5 denotes a hydroxyl group or an alkoxy or aralkoxy group, and in which when and R4 both denote a hydrogen atom, the centre of asymmetry C" at the substituent R3 is in the racemate form, or in the D-form or L-form. The dehydropeptides are useful as tumor-resolving and/or histolytic medicaments. Also included in the invention are methods for the preparation of said dehydropeptides, compositions contain- ing said dehydropepetides and methods for the use of said dehydropeptides and dehydropeptides, compositions

345085

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