C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/496 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 487/04 (2006.01)
Patent
CA 2494049
Compounds represented by structure (I) are disclosed, as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1', R1'', R2, R3, R4, R5, and R6, X1 and X2, Y, Z, Z1, Z2, Z3, and Z4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating cancer and fungal infection are also disclosed.
L'invention concerne des composés représentés par la structure (I), ainsi que des procédés permettant de préparer de tels composés. Ces procédés consistent à faire réagir une diacyldicétopipérazine avec un premier aldéhyde afin de produire un composé intermédiaire, et à faire réagir ce composé intermédiaire avec un second aldéhyde afin de produire une classe de composés présentant la structure générique, le premier aldéhyde et le second aldéhyde étant choisis dans le groupe constitué par un oxazolecarboxaldéhyde, un imidazolecarboxaldéhyde, un benzaldéhyde, des dérivés imidazolecarboxaldéhyde, et des dérivés de benzaldéhyde, de manière à former le composé décrit ci-dessus. R¿1?, R¿1? , R¿1? , R¿2?, R¿3?, R¿4?, R¿5?, et R¿6?, X¿1? et X¿2?, Y, Z, Z¿1?, Z¿2?, Z¿3?, et Z¿4? peuvent être définis chacun séparément d'une manière conforme au descriptif. L'invention concerne en outre des compositions et des méthodes de traitement du cancer et des infections fongiques.
Grodberg Jennifer
Hayashi Yoshio
Palladino Michael
Barrigar Intellectual Property Law
Nereus Pharmaceuticals Inc.
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