Delayed-release dosage forms of sertraline

Details Delayed-release dosage forms of sertraline Delayed-release dosage forms of sertraline

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2290969

Delayed-release dosage forms of sertraline which reduce Tmax and reduce side effects. The dosage forms are, in general, spatially delayed by being sensitive to their position along the gastrointestinal tract, or temporally delayed by being delayed for a preset period, independent of their position along the gastrointestinal tract. In vitro tests for identifying such dosage forms are presented.

Formes posologiques de sertraline, à action retardée, dont le Tmax et les effets secondaires sont réduits. Lesdites formes se caractérisent, en général, par une action retardée dans l'espace, c'est-à-dire qu'elles sont sensibles à leur emplacement le long du tractus gastro-intestinal, ou par une action retardée dans le temps sur une durée prédéterminée, quel que soit leur emplacement le long du tractus gastro-intestinal. Des essais in vitro pour l'identification desdites formes posologiques sont également décrits.

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