Delayed-release form of bromhexine and process for the...

A - Human Necessities – 61 – K

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A61K 9/22 (2006.01) A61K 9/20 (2006.01) A61K 9/24 (2006.01) A61K 9/28 (2006.01) A61K 9/50 (2006.01) A61K 31/135 (2006.01)

Patent

CA 1205384

ABSTRACT OF THE DISCLOSURE Delayed-release pharmaceutical compositions of bromhexine The present invention is directed to new delayed- release compositions containing bromhexine and/or one or more salt thereof and one or more acidic substances, in the form of spheroidal particles, or tablets, with a coating. The acidic substance may comprise, for example, edible organic acids, and the coating consists essentially of an acid-insoluble lacquer soluble in intestinal juice, the coating constituting about 2 to 30% by weight, relative to the weight of the uncoated spheroidal particles or tablets. The invention is also directed to processes for preparing delayed-release compositions of this kind.

406680

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