A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/135 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01) A61K 9/48 (2006.01) A61K 9/52 (2006.01) A61K 31/138 (2006.01)
Patent
CA 2158166
The invention concerns cylindrical retarded-action tablets hav- ing convex or planar upper and lower surfaces and made of .beta.- phenylpropiophenone derivatives of formula (I) acting as the active ingredient, in which R = n-propyl or 1,1-dimethylpropyl, and pharma- cologically acceptable salts of such derivatives, a) tablet height and diameter, independently of each other, being 1 to 3 mm; b) the con- centration of the active ingredient lying in the range from 81 to 99.9 % by wt. relative to the weight of the microtablet, neglecting the weight of any coating present; c) the density of the active ingredient being greater than 1; d) at least 80 % of the active ingredient being released between 3 hours and 24 hours when tested using the USP paddle model at 50 rpm; e) the rate of release being virtually independent of the pressure used to compress the tablet; f) the tablet containing no retarding-action auxiliaries but 0.1 to 5 % by wt. of a lubricant and 0 to 18.9 % by wt. of other usual auxiliaries. The invention also concerns a gelatin capsule containing 3 to 200 such tablets with the same or different release rates, plus a method of producing the tablets.
Buehler Volker
Fricke Helmut
Kolter Karl
Mueller-Peltzer Herbert
Abbott Gmbh & Co. Kg
Knoll Aktiengesellschaft
Torys Llp
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