Delayed release or extended-delayed release dosage forms of...

A - Human Necessities – 61 – K

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Details

A61K 9/48 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 31/428 (2006.01)

Patent

CA 2613107

The present invention is directed to pharmaceutical compositions that allow for once- daily dosage forms of pramipexole. The proposed delayed / extended release dosage form in a single dosage form is equivalent to the immediate release three-time daily regimen, and upon administration, provides average steady state blood levels of pramipexole. A once-a-day administration of pramipexole is advantageous over the thrice-a-day administration in terms of both patient compliance and reduced adverse events, thus providing better treatment of the conditions for which the pramipexole is indicated.

L'invention concerne des compositions pharmaceutiques conçues pour des formes de dosage quotidien monodose de pramipexole. La forme de dosage selon l'invention, à libération retardée/prolongée en monodose est équivalente à un régime de trois fois par jour à libération immédiate et fournit, après administration, des concentrations de pramipexole dans le sang à l'état stabilisé. Une administration monodose de pramipexole est avantageuse, par rapport à une administration à raison de trois fois par jour, à la fois sur le plan adhésion du patient au traitement, et sur le plan événements indésirables, lesquels sont réduits, ce qui procure une meilleure maîtrise des conditions pour lesquelles le pramipexole est indiqué.

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