Delayed release, oral dosage compositions that contain...

Details Delayed release, oral dosage compositions that contain... Delayed release, oral dosage compositions that contain...

A - Human Necessities

61

K

A61K 9/16 (2006.01)

Patent

CA 2752048

Pharmaceutical formulations exhibit a desirably low Cmax, among other properties, that contain particles of amorphous bardoxolone methyl, either in pure form or in the form of a solid dispersion, admixed with particles of a hydrophilic binding agent. Such formulations possess the advantage of higher oral bioavailability, relative to formulations based on the crystalline form of bardoxolone methyl.

La présente invention concerne des formulations pharmaceutiques présentant un Cmax faible souhaitée, entre autres propriétés, qui contiennent des particules amorphes de bardoxolone méthyle, soit sous une forme pure ou sous la forme d'une dispersion solide, mélangées avec des particules d'un agent de liaison hydrophile. De telles formulations présentent l'avantage d'une biodisponibilité orale supérieure, par rapport à des formations à base de cristalline de bardoxolone méthyle.

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