Delayed/sustained release of macromolecules

A - Human Necessities – 61 – K

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167/166, 167/103

A61K 9/22 (2006.01) A61K 9/00 (2006.01) A61K 9/32 (2006.01)

Patent

CA 1309347

25540-FF ABSTRACT OF THE DISCLOSURE This invention concerns novel, delayed/sustained release devices including methods of their manufacture and use. The devices comprise macromolecules, particularly polypeptide pharmaceuticals, and an initially partially-hydrated, non-biodegradable, hydrogel rate-limiting membrane.

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