Deleted sequences in m. bovis bcg/m. bovis or m....

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) C07K 14/35 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2368088

The invention concerns the isolation of nucleotide and peptide sequences in particular for differentiating, in diagnostic terms, an immunisation resulting from BCG vaccination of an infection by M. tuberculosis. Said sequences are either M. bovis BCG/M. bovis specific or M. tuberculosis specific. The invention also concerns a method for detecting said sequences, a method for detecting antibodies generated by the products expressing said sequences as well as kits for implementing said methods. Finally, the invention concerns novel vaccines.

La présente invention a pour objet la mise en évidence de séquences nucléotidiques et peptidiques permettant notamment de distinguer, en terme de diagnostic, une immunisation résultant d'une vaccination par le BCG d'une infection par M. tuberculosis. Les séquences en question sont spécifiques soit de M. bovis BCG/~i(M. bovis), soit de M. tuberculosis. La présente invention a également pour objet un procédé de détection des séquences en question, un procédé pour la détection d'anticorps générés par les produits d'expression de ces séquences ainsi que les kits pour mettre en oeuvre ces procédés. Enfin, la présente invention a pour objet de nouveaux vaccins.

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