Deletion analogues of magainin peptides

Details Deletion analogues of magainin peptides Deletion analogues of magainin peptides

C - Chemistry, Metallurgy

07

K

530/7.08, 530/7.

C07K 14/46 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2004991

A compound comprising a deletion analogue of an amide or carboxy-terminated Magainin I of the following structural formula using the single letter amino acid code: G I G K F L H S A G K F G K A F V G E I M K S 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 and wherein at least one of amino acid residues 15 through 23 is omitted; or a deletion analogue of an amide or carboxy-terminated Magainin II of the following structural formula using the single letter amino acid code: G I G K F L H S A K K F G K A F V G E I M N S 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 and wherein at least one of amino acid residues 15 through 23 is omitted. These compounds can be effectively used as pharmaceutical compositions.

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