C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/20 (2006.01) A61K 39/106 (2006.01) C07K 14/28 (2006.01) C12N 1/21 (2006.01) C12N 1/36 (2006.01)
Patent
CA 2139655
The invention features of nontoxigenic, genetically stable mutant strains of V cholerae and a method of making which are useful as live, oral vaccines for inducing immunological protection against cholera. The mutant strains are genetically engineered mutants which lack DNA encoding a functional ctxA subunit which is responsible for many of the symptoms of cholera. The strains also lack any functional attRS1 sequences which are required for recombination and amplification of the CTX genetic element. These strains are safe because they can not recombine with the wild type attRS1-containing vehicles which include the ctxA-encoding DNA.
Beattie David
Killeen Kevin
Lu Yichen
Mekalanos John J.
Celldex Therapeutics Inc.
President And Fellows Of Harvard College
Smart & Biggar
Virus Research Institute
LandOfFree
Deletion mutants as vaccines for cholera does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Deletion mutants as vaccines for cholera, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Deletion mutants as vaccines for cholera will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1941218