Deletion mutants of flagellin and methods of use

Details Deletion mutants of flagellin and methods of use Deletion mutants of flagellin and methods of use

A - Human Necessities

61

K

A61K 39/02 (2006.01) C07K 14/255 (2006.01)

Patent

CA 2721246

Compositions that include Toll-like Receptor 5 agonists and at least a portion of at least one influenza antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to viral infection.

Il est possible demployer des compositions qui renferment des agonistes du TLR 5 (Toll-like Receptor 5) et au moins une partie dau moins un antigène du virus de la grippe dans des procédés qui stimulent une réponse immunitaire chez un sujet, en particulier, une réponse immunitaire protectrice chez un sujet. Les compositions peuvent être associées à des particules et employées dans les procédés dans des doses relativement basses pour fournir une immunité protectrice contre une infection virale.

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