C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/21 (2006.01) A61K 38/16 (2006.01) C07K 19/00 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2698357
The invention provides mutated, cytotoxic forms of Pseudomonas exotoxin A (PE) comprising a furin cleavage sequence conjugated or fused directly to residues 395-613 of PE or variants of that sequence. These minimal forms of PE are smaller than previous cytotoxic forms of PE, reduce non-specific toxicity, and reduce immunogenicity due to domain II or domain Ib of PE. The invention further provides nucleic acids encoding said PEs, chimeric molecules containing them, and methods of use thereof.
L'invention concerne des formes cytotoxiques mutées de l'exotoxine A de Pseudomonas (PE) qui comprennent une séquence de clivage par la furine conjuguée ou fusionnée directement à des résidus 395-613 de la PE ou des variantes de cette séquence. Ces formes minimales de la PE sont plus petites que les formes cytotoxiques antérieures de la PE, réduisent la toxicité non spécifique et réduisent l'immunogénicité due au domaine II ou au domaine Ib de la PE. L'invention concerne également des acides nucléiques qui codent pour lesdites PE, des molécules chimères qui les contiennent et leurs procédés d'utilisation.
Fitzgerald David
Pastan Ira H.
Weldon John
Fetherstonhaugh & Co.
The Government Of The United States Of America As Represented By The Se Cretary Of The Department Of Health And
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